The game becomes more interesting as you acquire more blueprints. At first it’s the runs are mostly about luck. Then you starting gaining the ability to craft Nano Injectors to preserve your Nano Bots and repair your ship when you need them most.
By now, I completed runs with all the ships, I could say. “Could say”, because once you collect all 8 DNA samples the corrupt admiral appears in a cruiser, which is impenetrable for your weapons, and you need to launch missiles from a silo at it.