Second region is just an exercise in bad writing. We are told that Paolo is indispensable, but the game never actually demonstrates why it is so. What happened to “show, don’t tell”? It’s unsurprising that they killed of the best characters in the game, Jonron and El Tiger. Made all the others look really bad. And those are the only two characters I actually could care about.
Pablo gets captured by The Doctor. Presumably to detransition her? Then when we try to rescue her, the Doctor captures us too, and puts a cellphone with a poison inside our belly. This one of the worst plot twists brings one of the best episodes in the game, where we ride in a car hallucinating our dead friends, that tell Dani he doesn’t care about the Revolution, and just likes shooting people. A very deep self reflection.
Then we cut out belly open and extract the phone. Not clear why it had to be a phone in the first place.
The mission where you have to follow the pipes is kind of okay. At least it’s not capturing yet another base. Then there’s the revelation that El Tigre killed one of his comrades, Lobo, because he was going to become the next dictator. As far as I remember Lobo was the name for Vaas character from Far Cry 3.